If you're a Firefox user and you like to keep things simple, this add-on is pretty damn cool. It's called Ubiquity. Mozilla Labs puts out some pretty cool software, and this is no exception. I've been using this add-on at home and work for 3 or 4 days now and I've gotta say it makes the web a lot easier for me. I've embedded their demo video below, it does a much better job of explaining the software than I ever could.
I use Firefox, almost exclusively, for all of my internet needs. I like the rendering, the plug-ins, and the way it looks. I think, for work at least, the reason I like Firefox the most is the ability to set a proxy server independent from the Windows proxy settings.